Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT
10.1007/s13139-019-00611-z
- Author:
Saurabh ARORA
1
;
Nishikant A DAMLE
;
Rachna MEEL
;
Sanjay SHARMA
;
Seema SEN
;
Chandrasekar BAL
;
Kanak LATA
;
Sneha PRAKASH
;
Divya YADAV
;
Meivel ANGAMUTHU
Author Information
1. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. nkantdamle@gmail.com, docsaurabharora@gmail.com, csbal@hotmail.com, kanaklata777@gmail.com, sneha.4teen@gmail.com, mynamedivya.1991@gmail.com, drmeivel@gmail.com
- Publication Type:Case Report
- Keywords:
Orbital IgG4 disease;
Somatostatin receptors;
⁶⁸Ga-DOTANOC PET/CT
- MeSH:
Conjunctiva;
Eyelids;
Immunoglobulin G;
Immunoglobulins;
Inflammation;
Lacrimal Apparatus;
Muscles;
Orbit;
Orbital Diseases;
Pancreatitis;
Plasma Cells;
Positron-Emission Tomography and Computed Tomography;
Receptors, Somatostatin
- From:Nuclear Medicine and Molecular Imaging
2019;53(6):432-435
- CountryRepublic of Korea
- Language:English
-
Abstract:
Immunoglobulin G4 (IgG4)–related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using ⁶⁸Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).
