Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET
10.1007/s13139-019-00609-7
- Author:
Jieun JEONG
1
;
Young Jin JEONG
;
Kyung Won PARK
;
Do Young KANG
Author Information
1. Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 602-715, South Korea. dykang@dau.ac.kr, jje5539@gmail.com
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
F-18 florbetaben;
Healthy;
SUVR
- MeSH:
Adult;
Aged;
Alzheimer Disease;
Amyloid;
Brain;
Cerebellar Cortex;
Diagnosis;
Frontal Lobe;
Humans;
Parietal Lobe;
Plaque, Amyloid;
Positron-Emission Tomography;
Prospective Studies;
Reference Values
- From:Nuclear Medicine and Molecular Imaging
2019;53(5):334-339
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).METHODS: We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50??0 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.RESULTS: The distribution of amyloid beta for each brain region revealed no age-related trends (p > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).CONCLUSIONS: We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease.
