Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
10.20307/nps.2019.25.4.304
- Author:
Ki Sun KWON
1
;
Hyun LIM
;
Yong Soo KWON
;
Hye Ri CHOI
;
Myong Jo KIM
;
Ji Hye YOO
;
Nam Ho YOO
;
Hyun Pyo KIM
Author Information
1. College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea. hpkim@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Oplopanax elatus;
rheumatoid arthritis;
adjuvant-induced arthritis;
mitogen-activated protein kinase
- MeSH:
Animals;
Arthritis;
Arthritis, Rheumatoid;
Cytokines;
Edema;
Herbal Medicine;
Macrophages;
Models, Animal;
Nitric Oxide;
Oplopanax;
Protein Kinases;
Rats;
RAW 264.7 Cells;
Water
- From:Natural Product Sciences
2019;25(4):304-310
- CountryRepublic of Korea
- Language:English
-
Abstract:
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in lipopolysaccharide-treated macrophages, RAW 264.7 cell. OE reduces inducible nitric oxide (NO) synthase-induced NO production, and interferes with mitogen-activated protein kinase activation pathways. In the present study, the pharmacological action of the water extract of OE was examined to establish anti-arthritic action, using a rat model of adjuvant-induced arthritis (AIA). The water extract of OE administered orally inhibited AIA-induced arthritis at (100 – 300) mg/kg/day. The paw edema was significantly decreased, in combination with reduced production of pro-inflammatory cytokines. The action mechanism includes an inhibition of MAPKs/nuclear transcription factor-κB activation. These new findings strongly suggest that OE possesses anti-arthritic action, and may be used as a therapeutic agent in inflammation-related disorders, particularly in arthritic condition.
