Intraindividual Comparison between Gadoxetate-Enhanced Magnetic Resonance Imaging and Dynamic Computed Tomography for Characterizing Focal Hepatic Lesions: A Multicenter, Multireader Study
- Author:
Chansik AN
1
;
Chang Hee LEE
;
Jae Ho BYUN
;
Min Hee LEE
;
Woo Kyoung JEONG
;
Sang Hyun CHOI
;
Do Young KIM
;
Young Suk LIM
;
Young Seok KIM
;
Ji Hoon KIM
;
Moon Seok CHOI
;
Myeong Jin KIM
Author Information
- Publication Type:Multicenter Study
- Keywords: Hepatocellular carcinoma; Magnetic resonance imaging; Computed tomography; Contrast media; Data systems; Gadolinium ethoxybenzyl DTPA
- MeSH: Academies and Institutes; Carcinoma, Hepatocellular; Contrast Media; Humans; Information Systems; Liver; Liver Diseases; Magnetic Resonance Imaging; Retrospective Studies; Tertiary Care Centers
- From:Korean Journal of Radiology 2019;20(12):1616-1626
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To compare the diagnostic accuracy of dynamic computed tomography (CT) and gadoxetate-enhanced magnetic resonance imaging (MRI) for characterization of hepatic lesions by using the Liver Imaging Reporting and Data System (LI-RADS) in a multicenter, off-site evaluation.MATERIALS AND METHODS: In this retrospective multicenter study, we evaluated 231 hepatic lesions (114 hepatocellular carcinomas [HCCs], 58 non-HCC malignancies, and 59 benign lesions) confirmed histologically in 217 patients with chronic liver disease who underwent both gadoxetate-enhanced MRI and dynamic CT at one of five tertiary hospitals. Four radiologists at different institutes independently reviewed all MR images first and the CT images 4 weeks later. They evaluated the major and ancillary imaging features and categorized each hepatic lesion according to the LI-RADS v2014. Diagnostic performance was calculated and compared using generalized estimating equations.RESULTS: MRI showed higher sensitivity and accuracy than CT for diagnosing hepatic malignancies; the pooled sensitivities, specificities, and accuracies for categorizing LR-5/5V/M were 59.0% vs. 72.4% (CT vs. MRI; p < 0.001), 83.5% vs. 83.9% (p = 0.906), and 65.3% vs. 75.3% (p < 0.001), respectively. CT and MRI showed comparable capabilities for differentiating between HCC and other malignancies, with pooled accuracies of 79.9% and 82.4% for categorizing LR-M, respectively (p = 0.139).CONCLUSION: Gadoxetate-enhanced MRI showed superior accuracy for categorizing LR-5/5V/M in hepatic malignancies in comparison with dynamic CT. Both modalities had comparable accuracies for distinguishing other malignancies from HCC.
