Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity
- Author:
Bahar ÖZCABI
1
;
Salih DEMIRHAN
;
Mesut AKYOL
;
Hatice ÖZTÜRKMEN AKAY
;
Ayla GÜVEN
Author Information
- Publication Type:Original Article
- Keywords: Childhood obesity; Lipid accumulation product; Nonalcoholic fatty liver disease; Total cholesterol/high-density lipoprotein cholesterol; Waist circumference
- MeSH: Adolescent; Adult; Child; Cholesterol; Fasting; Female; Homeostasis; Humans; Insulin; Insulin Resistance; Lipid Accumulation Product; Lipoproteins; Medical Records; Non-alcoholic Fatty Liver Disease; Obesity; Pediatric Obesity; Puberty; Ultrasonography; Uric Acid; Waist Circumference
- From:Korean Journal of Pediatrics 2019;62(12):450-455
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults.PURPOSE: Here we evaluated the ability of LAP to predict NAFLD in obese children.METHODS: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist circumference (WC) (cm) – 58]×triglycerides (mmol/L) in girls; [WC (cm) – 65]×triglycerides (mmol/L) in boys. The minLAP and adjLAP were described (3% and 50% of WC values, respectively) and the total/high-density lipoprotein cholesterol index (TC/HDL-C) was calculated. NAFLD was observed on ultrasound, and patients were divided into 3 groups by steatosis grade (normal, grade 0; mild, grade 1; moderate-severe, grade 2–3). The area under the curve (AUC) and appropriate index cutoff points were calculated by receiver operator characteristic analysis.RESULTS: LAP was positively correlated with puberty stage (rho=0.409; P<0.001), fasting insulin (rho=0.507; P<0.001), homeostasis model assessment of insulin resistance (rho=0.470; P<0.001), uric acid (rho=0.522; P<0.001), and TC/HDL-C (rho=0.494; P<0.001) and negatively correlated with HDL-C (rho=-3.833; P<0.001). LAP values could be used to diagnose hepatosteatosis (AUC=0.698; P=0.002). The LAP, adjLAP, and minLAP cutoff values were 42.7 (P=0.002), 40.05 (P=0.003), and 53.47 (P=0.08), respectively. For LAP, the differences between the normal and mild groups (P=0.035) and the normal and moderate-severe groups were statistically significant (P=0.037), whereas the difference between the mild and moderate-severe groups was not (P>0.005). There was a statistically significant difference between the normal and mild groups for adjLAP (P=0.043) but not between the other groups (P>0.005). There was no significant intergroup difference in minLAP (P>0.005).CONCLUSION: LAP is a powerful and easy tool to predict NAFLD in childhood. If LAP is ≥42.7, NAFLD should be suspected. This is the first study to assess LAP diagnostic accuracy for childhood obesity.
