Contact Lens Induced Limbal Stem Cell Deficiency: Clinical Features in Korean Patients
- Author:
Seung Chan LEE
1
;
Joon Young HYON
;
Hyun Sun JEON
Author Information
- Publication Type:Original Article
- Keywords: Complications; Hydrophilic contact lenses; Limbal stem cell deficiency
- MeSH: Contact Lenses, Hydrophilic; Demography; Female; Fluorescein; Follow-Up Studies; Humans; Medical Records; Myopia; Outcome Assessment (Health Care); Retrospective Studies; Stem Cells; Visual Acuity
- From:Korean Journal of Ophthalmology 2019;33(6):500-505
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To describe the clinical features of Korean patients with contact lens-induced limbal stem cell deficiency (CL-LSCD).METHODS: Medical records of 22 patients who were diagnosed with CL-LSCD between 2014 and 2019 were reviewed retrospectively. Outcome measures included demographics, clinical presentation, treatment, clinical course, and pattern of contact lens (CL) wear.RESULTS: Forty-two eyes of 22 patients were found to have typical changes associated with CL-LSCD. Twenty (91%) patients were women and mean age was 36 ± 12 years. All patients had myopia with mean spherical equivalent of −7.52 ± 3.2 diopter. Twenty (91%) patients had bilateral disease and the location of limbal involvement was diffuse in 20 eyes (47.6%) and partial in 22 eyes (52.4%, superior in 20 eyes and inferior in 2 eyes). Fourteen (63.6%) patients complained of decreased visual acuity. Average period of CL wear was 14 ± 9 years. Four patients used cosmetic colored CLs and four patients had a history of overnight CL wear. All 12 patients who completed follow-up (28 ± 42 weeks) showed improvement in visual acuity and ocular surface condition after cessation of CL wear and medical treatment. Of them, five (42%) patients showed full recovery while seven (58%) showed partial recovery.CONCLUSIONS: If a patient with a history of CL wear for an extended period of time presents with decreased visual acuity, practitioners should perform detailed examinations with suspicion of CL-LSCD, including fluorescein staining. CL-LSCD is usually reversible and close follow-up with conservative treatment is recommended as the initial treatment option.
