The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
10.4093/dmj.2016.40.4.253
- Author:
Kimberley L WAY
1
;
Daniel A HACKETT
;
Michael K BAKER
;
Nathan A JOHNSON
Author Information
1. University of Sydney Faculty of Health Sciences, Lidcombe, Australia. kway2744@uni.sydney.edu.au, nathan.johnson@sydney.edu.au
- Publication Type:Meta-Analysis ; Review
- Keywords:
Aerobic training;
Glucose tolerance test;
Hyperinsulinaemic euglycaemic clamp;
Insulin resistance;
Resistance training
- MeSH:
Adult;
Data Collection;
Diabetes Mellitus, Type 2*;
Glucose Tolerance Test;
Humans;
Insulin Resistance*;
Insulin*;
Resistance Training
- From:Diabetes & Metabolism Journal
2016;40(4):253-271
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus (T2DM) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size (ES) for the effect of exercise on insulin sensitivity (ES, –0.588; 95% confidence interval [CI], –0.816 to –0.359; P<0.001). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise (ES, –0.702; 95% CI, –1.392 to –0.012; P=0.046); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session (ES, –0.890; 95% CI, –1.675 to –0.105; P=0.026). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session.
