Langerhans Cell Sarcoma of the Scalp with Concomitant Multiple Cervical Lymph Node and Adjacent Soft Tissue Involvement: A Case Report
- Author:
Man Hoon HAN
1
;
Jun Young KIM
;
Weon Ju LEE
;
Seok Jong LEE
Author Information
1. Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.
- Publication Type:Case Report
- Keywords:
Langerhans cell sarcoma;
Lymph node;
Parotid gland;
Scalp;
Soft tissue
- MeSH:
Biopsy;
Biopsy, Fine-Needle;
Cytoplasm;
Drug Therapy;
Electrons;
Female;
Histiocytosis, Langerhans-Cell;
Humans;
Langerhans Cell Sarcoma;
Langerhans Cells;
Lymph Nodes;
Middle Aged;
Neck;
Parotid Gland;
Prognosis;
Scalp;
World Health Organization
- From:Korean Journal of Dermatology
2019;57(9):538-543
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Currently, the World Health Organization classifies Langerhans cell tumors into Langerhans cell histiocytosis and Langerhans cell sarcoma (LCS). LCS is a neoplastic proliferation of Langerhans cells showing malignant cytological features and aggressive clinical behavior with grave prognosis. Only a few cases have been reported in the available literature; therefore, to date, no definitive treatment has been established. A 64-year-old woman presented with a 1-year history of an asymptomatic, slow-growing erythematous nodule measuring 0.7 cm on her scalp. The patient also reported a 3-month history of a painful swelling on the right side of her neck. Histopathological examination of a scalp biopsy specimen revealed sheets of atypical cells with hyperchromatic nucleoli and clear cytoplasm. Immunohistochemical studies revealed malignant cells positive for CD1a, CD31, CD68, and S-100 expression. Additionally, positron emission tomography–computed tomography and fine-needle aspiration revealed LCS of the cervical lymph nodes and surrounding soft tissue. We recommended surgical excision and adjunctive chemotherapy; however, the patient refused treatment and died of the disease 28 months later.
