Evolutionary Genetic Models of Mental Disorders
- Author:
Hanson PARK
1
Author Information
1. Department of Anthropology, Seoul National University College of Social Science, Seoul, Korea. hansonpark@snu.ac.kr
- Publication Type:Review
- Keywords:
Evolutionary psychiatry;
Mental disorder;
Balancing selection
- MeSH:
Mental Disorders;
Models, Genetic;
Prevalence
- From:Journal of the Korean Society of Biological Psychiatry
2019;26(2):33-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.
