NR3C1 Polymorphisms for Genetic Susceptibility to Schizophrenia
- Author:
Joo Seok PARK
1
;
Sang Min LEE
;
Jong Woo KIM
;
Won Sub KANG
Author Information
1. Department of Psychiatry, Kyung Hee University Hospital, Seoul, Korea. menuhinwskang@khu.ac.kr
- Publication Type:Original Article
- Keywords:
NR3C1 gene;
Schizophrenia;
Genetic polymorphisms
- MeSH:
Alleles;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Hydrocortisone;
Logistic Models;
Odds Ratio;
Polymorphism, Genetic;
Polymorphism, Single Nucleotide;
Receptors, Glucocorticoid;
Schizophrenia;
Stress, Psychological;
Wills
- From:Journal of the Korean Society of Biological Psychiatry
2019;26(2):88-93
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Psychological stress has been known to increase the risk of schizophrenia. Because stress responses are mainly mediated by cortisol, the action of the glucocorticoid receptors (Nuclear Receptor Subfamily 3 Group C Member 1, NR3C1) is possibly related to the pathogenesis of schizophrenia. In this study, we investigated the associations between polymorphisms of NR3C1 and schizophrenia.METHODS: Four single nucleotide polymorphisms (SNPs) (rs17100236, rs2963155, rs9324924, and rs7701443) of NR3C1 were genotyped in 208 patients with schizophrenia and 339 healthy individuals. A chi-square test was performed to test differences in allele distributions among groups. A multiple logistic regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and multiple inheritance models to analyze the associations between schizophrenia and SNPs (the dominant, recessive and additive models).RESULTS: The minor allele frequencies of two SNPs were significantly higher in the schizophrenia group than in those of the control group (rs2963155 G > A : 0.25 vs. 0.18, p = 0.0066 ; rs7701443 A > G : 0.40 vs. 0.33, p = 0.012). The genotype frequencies of two SNPs were found to be significantly different between patients with schizophrenia and controls in the dominant model (rs2963155 : AG/GG vs. AA, OR = 1.66, 95% CI = 1.16–2.38, p = 0.0055, rs7701443 : AG/AA vs. GG, OR = 1.61, 95% CI = 1.11–2.34, p = 0.01) and the log-additive model (rs2963155 : AG vs. GG vs. AA, OR = 1.54, 95% CI = 1.13–2.10, p = 0.0067).CONCLUSIONS: This study showed significant associations between NR3C1 polymorphisms and schizophrenia. It suggests that NR3C1 may play a role in the pathogenesis of schizophrenia.
