Clinical features and outcomes in kidney transplant recipients with renal cell carcinoma: a single-center study
- Author:
Keun Hoi PARK
1
;
Jung A YOON
;
Hak Soo KIM
;
Hyosang KIM
;
Su Kil PARK
;
Young Hoon KIM
;
Bumsik HONG
;
Dalsan YOU
;
In Gab JEONG
;
Chung Hee BAEK
Author Information
- Publication Type:Original Article
- Keywords: End-stage renal disease; Kidney transplantation; Recurrence; Renal cell carcinoma; Survival
- MeSH: Asian Continental Ancestry Group; Carcinoma, Renal Cell; Graft Rejection; Graft Survival; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kidney; Nephrectomy; Recurrence; Retrospective Studies; Transplant Recipients
- From:Kidney Research and Clinical Practice 2019;38(4):517-524
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Previous studies have recommended a 2- to 5-year waiting time prior to kidney transplantation (KT) in patients with end-stage renal disease (ESRD) and symptomatic renal cell carcinoma (RCC) and no delay for incidental early-stage RCC. Data on Asian KT recipients are unavailable.METHODS: This is a Korean single-center retrospective study on 35 KT recipients with ESRD and RCC. Patients were classified into two groups: early KT (KT performed within 1 year after nephrectomy for RCC, including KT with simultaneous nephrectomy) and delayed KT (KT performed over than 1 year after nephrectomy for RCC). Patient survival, graft survival, and cancer recurrence were compared between both groups.RESULTS: There were no statistically significant differences in patient survival (P = 0.388), graft survival (P = 0.317), or graft rejection rate (P = 0.207) between the early and delayed KT groups. Additionally, there were no differences in pathological characteristics or RCC stage other than cancer histology: acquired cystic disease-associated RCC (47.4%) was the most common RCC type in the early KT group, whereas clear cell type (62.5%) was the most common RCC type in the delayed KT group. No RCC recurrence was observed.CONCLUSION: Patients with early-stage and asymptomatic RCC do not require a mandatory observational period prior to KT after curative nephrectomy
