Drug-induced nephrotoxicity
10.5124/jkma.2020.63.1.30
- Author:
Eunjin BAE
1
;
Tae Won LEE
;
Dong Jun PARK
Author Information
1. Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Jinju, Korea. drpdj@gnuh.co.kr
- Publication Type:Original Article
- Keywords:
Glomerulus;
Kidney tubules;
Renal insufficiency;
Pharmaceutical preparations;
Toxicity
- MeSH:
Adult;
Delivery of Health Care;
Humans;
Kidney Tubules;
Pharmaceutical Preparations;
Renal Insufficiency;
Renal Insufficiency, Chronic;
Risk Factors
- From:Journal of the Korean Medical Association
2020;63(1):30-35
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drugs are a common cause of acute and chronic kidney disease and contribute to patient morbidity and increased healthcare utilization. Drug-induced nephrotoxicity is approximately 14% to 26% in adults and tends to increase among certain patients and/or with complex clinical conditions. Unfortunately, apart from conservative management, including drug withdrawal, no effective treatment is known for this condition. Therefore, in order to reduce the frequency of drug-induced nephrotoxicity, early recognition of renal toxicity and appropriate prevention strategies, such as understanding the exact mechanisms of renal injury, patient and drug-related risk factors, and preemptive measures are needed. In this review, we will present the mechanisms of drug-induced nephrotoxicity and general preventive strategies for clinical physicians.
