MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma
- Author:
Yeseul KIM
1
;
Jongmin SIM
;
Hyunsung KIM
;
Seong Sik BANG
;
Seungyun JEE
;
Sungeon PARK
;
Kiseok JANG
Author Information
- Publication Type:Original Article
- Keywords: Lung neoplasms; Adenocarcinoma; Stage; Recurrence; MicroRNAs
- MeSH: Adenocarcinoma; Disease-Free Survival; Gene Expression; Humans; Lung Neoplasms; Lung; MicroRNAs; Polymerase Chain Reaction; Recurrence; RNA, Small Untranslated
- From:Journal of Pathology and Translational Medicine 2019;53(6):354-360
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is commonly dysregulated in malignant tumors. The purpose of this study was to analyze the expression of microRNA-374a (miR-374a) in lung adenocarcinoma and correlate its expression with various clinicopathological characteristics.METHODS: The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays. The correlation between miR-374a expression and clinicopathological parameters, including clinical outcome, was further analyzed.RESULTS: High miR-374 expression was correlated with advanced pT category (chi-square test, p=.004) and pleural invasion (chi-square test, p=.034). Survival analysis revealed that patients with high miR-374a expression had significantly shorter disease-free survival relative to those with low miR-374a expression (log-rank test, p=.032).CONCLUSIONS: miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery.
