Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy
- Author:
Kwang Sun SUH
1
;
Song Yi CHOI
;
Go Eun BAE
;
Dae Eun CHOI
;
Min kyung YEO
Author Information
- Publication Type:Case Report
- Keywords: Anti-glomerular basement membrane disease; Immunoglobulin A; Crescentic glomerulonephritis
- MeSH: Adult; Anti-Glomerular Basement Membrane Disease; Antibodies; Antigen-Antibody Complex; Azotemia; Basement Membrane; Biopsy; Cyclophosphamide; Female; Glomerulonephritis; Glomerulonephritis, IGA; Hematuria; Humans; Immunoglobulin A; Immunoglobulin G; Methylprednisolone; Nephritis; Proteinuria
- From:Journal of Pathology and Translational Medicine 2019;53(6):399-402
- CountryRepublic of Korea
- Language:English
- Abstract: Anti–glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.
