Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease
10.12997/jla.2020.9.1.153
- Author:
Zenaida ENCHILL
1
;
Connor LANTZ
;
Edward B THORP
Author Information
1. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ebthorp@northwestern.edu
- Publication Type:Review
- From:Journal of Lipid and Atherosclerosis
2020;9(1):153-161
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are correlated with macrophage activation and macrophage polarization of the transcriptome and secretome. In this setting, non-coding RNAs (ncRNAs) may be as abundant as protein-coding genes and are increasingly recognized as significant modulators of macrophage gene expression and cytokine secretion, although the functions of most ncRNAs—and in particular, long non-coding RNAs—remain unknown. Herein, we discuss a subset of specific ncRNAs of interest in macrophages in atherosclerosis and during myocardial inflammation.
