Efficacy of dual antiplatelet therapy as premedication before diagnostic cerebral digital subtraction angiography
10.7461/jcen.2019.21.3.131
- Author:
Yoon Hee CHOO
1
;
Young Jin JUNG
;
Chul Hoon CHANG
;
Jong Hoon KIM
Author Information
1. Department of Neurosurgery, Yeungnam University College of Medicine, Daegu, Republic of Korea. kjhns@yu.ac.kr
- Publication Type:Original Article
- Keywords:
digital subtraction angiography;
antiplatelet therapy;
premedication;
thromboembolism
- MeSH:
Aneurysm;
Angiography, Digital Subtraction;
Diplopia;
Female;
Humans;
Incidence;
Magnetic Resonance Imaging;
Male;
Platelet Aggregation Inhibitors;
Premedication;
Retrospective Studies;
Stroke;
Thromboembolism
- From:Journal of Cerebrovascular and Endovascular Neurosurgery
2019;21(3):131-137
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Several studies have reported that periprocedural dual antiplatelet therapy lowers the incidence of thromboembolic complications (TEC) associated with coiling of unruptured aneurysms. We hypothesized that preprocedural administration of dual antiplatelet agents (aspirin and cilostazol) for 7days may reduce the risk of complications associated with diagnostic cerebral digital subtraction angiography (DSA).METHODS: We retrospectively reviewed the records of patients who underwent diagnostic cerebral DSA between September 2015 and April 2018. Of the 419 patients included (149 men, 270 women, mean age 58.5 years), 221 (72 men, 149 women, mean age 57.8 years) who underwent cerebral DSA between September 2015 and June 2016 were not premedicated with antiplatelet therapy. The remaining 198 (77 men, 121 women, mean age 59.4 years) who underwent cerebral DSA between July 2016 and April 2018 were premedicated with dual antiplatelet therapy (aspirin and cilostazol). We defined ischemic stroke as a cerebral DSA-induced complication identified on magnetic resonance imaging (MRI) among patients with neurological symptoms.RESULTS: Of the 221 patients who did not receive antiplatelet therapy, 210 (95.0%) showed no neurological symptoms; however, 11 (5.0%) developed neurological symptoms with MRI-proven ischemic stroke, which represents a TEC. Of the 198 patients who received dual antiplatelet therapy, 196 patients (99.0%) showed no evidence of TEC. The remaining 2 (1.0%) developed diplopia and motor weakness each, and MRI confirmed acute ischemic stroke (p=0.019).CONCLUSIONS: The use of dual antiplatelet agents (aspirin and cilostazol) for 7 days before DSA may reduce the risk of cerebral DSA-induced TEC.
