A Case of Hunter Syndrome.
- Author:
Seok Yong AHN
1
;
Yoonhee LEE
;
Soo Young JEON
;
Baek Keun LIM
;
Won Soo LEE
Author Information
1. Department of Dermatology,Yonsei University Wonju College of Medicine, Wonju, Korea. leewonsoo@yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Hunter syndrome;
Mongolian spots;
Pebbling of the skin
- MeSH:
Animals;
Arm;
Biopsy;
Collagen;
Contracture;
Dermatan Sulfate;
Dermis;
Hand;
Heparitin Sulfate;
Hoof and Claw;
Intelligence;
Leukocytes;
Mongolian Spot;
Mucins;
Mucopolysaccharidosis II;
Nose;
Plasma;
Scapula;
Skin;
Thigh
- From:Korean Journal of Dermatology
2008;46(7):928-932
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of Hunter syndrome in a 4 year old boy, who presented with firm skin colored papules and nodules that coalesce to form a reticular pattern (pebbling of the skin) with extensive Mongolian spots. The lesions are arranged bilaterally and symmetrically over the scapulae, upper arm and lateral aspects of the thighs. He also has low intelligence, coarse face, saddle nose and claw hand contracture of both hands. The result of qualitative analysis of urine was positive for dermatan sulfate and heparan sulfate. And enzyme activity of iduronate-2-sulfatase is decreased in plasma and leukocyte. A skin biopsy specimen section stained with hematoxylin-eosin showed widely separated collagen bundles in the dermis associated with mucin deposition.
