Bisphenols and Thyroid Hormone
10.3803/EnM.2019.34.4.340
- Author:
Min Joo KIM
1
;
Young Joo PARK
Author Information
1. Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
- Publication Type:Review
- Keywords:
Bisphenol A;
Endocrine disruptors;
Thyroid hormones;
Receptors, thyroid hormone
- MeSH:
Endocrine Disruptors;
Epidemiologic Studies;
Estrogens;
Humans;
In Vitro Techniques;
Receptors, Thyroid Hormone;
Thyroid Gland;
Thyroid Hormones
- From:Endocrinology and Metabolism
2019;34(4):340-348
- CountryRepublic of Korea
- Language:English
-
Abstract:
In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health. BPA has estrogenic activity and is regarded as a representative endocrine disruptor. In addition, mounting evidence indicates that BPA can disrupt thyroid hormone and its action. This review examined human epidemiological studies to investigate the association between BPA exposure and thyroid hormone levels, and analyzed in vivo and in vitro experiments to identify the causal relationship and its mechanism of action. BPA is involved in thyroid hormone action not only as a thyroid hormone receptor antagonist, but also through several other mechanisms. Since the use of bisphenols other than BPA has recently increased, we also reviewed the effects of other bisphenols on thyroid hormone action.
