Impact of Subtotal Parathyroidectomy on Clinical Parameters and Quality of Life in Hemodialysis Patients with Secondary Hyperparathyroidism
10.3803/EnM.2019.34.4.367
- Author:
Mohamed Mimi Abd Elgawwad EL-KHOLEY
1
;
Ghada El said IBRAHIM
;
Osama Ibrahim ELSHAHAT
;
Ghada EL-KANNISHY
Author Information
1. Nephrology Unit, Mansoura New General Hospital, Mansoura, Egypt.
- Publication Type:Original Article
- Keywords:
Quality of life;
Renal dialysis;
Hyperparathyroidism, secondary;
Parathyroidectomy
- MeSH:
Blood Cell Count;
Calcium;
Humans;
Hyperparathyroidism;
Hyperparathyroidism, Secondary;
Kidney Diseases;
Kidney Failure, Chronic;
Longitudinal Studies;
Magnesium;
Parathyroid Hormone;
Parathyroidectomy;
Phosphorus;
Quality of Life;
Renal Dialysis;
Weight Gain;
Weights and Measures
- From:Endocrinology and Metabolism
2019;34(4):367-373
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Impairment of quality of life (QOL) is a key clinical characteristic of patients with end-stage renal disease (ESRD), and can be especially severe in the presence of secondary hyperparathyroidism (SHPT). Despite the proven success of parathyroidectomy (PTX) in controlling biochemical parameters in patients with severe SHPT, evidence is lacking regarding the effects of PTX on various clinical outcomes, including QOL.METHODS: Twenty ESRD patients on maintenance hemodialysis with SHPT who underwent subtotal PTX were included in an observational longitudinal study. All studied patients underwent history-taking, clinical examinations, and laboratory investigations, including a complete blood count and measurements of serum calcium, phosphorus, magnesium, parathyroid hormone (PTH), and albumin levels preoperatively and at 3 months postoperatively. QOL was assessed before surgery and at 3 months after surgery using the Kidney Disease Quality of Life 36-Item Short-Form instrument.RESULTS: After PTX, significant decreases in serum PTH and phosphorus levels were observed, as well as a significant increase in serum magnesium levels. Significant weight gain and improvements of QOL were also detected postoperatively.CONCLUSION: Subtotal PTX seems to be an efficient alternative to medical management in uncontrolled cases of SHPT, as it is capable of controlling the biochemical derangements that occur in hyperparathyroidism. Furthermore, PTX had a beneficial effect on clinical outcomes, as shown by weight gain and improvements in all QOL scales.
