Pathology of C3 Glomerulopathy
10.3339/jkspn.2019.23.2.93
- Author:
Su Jin SHIN
1
;
Yoonje SEONG
;
Beom Jin LIM
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Korea. bjlim@yuhs.ac
- Publication Type:Review
- Keywords:
C3 glomerulopathy;
C3 glomerulonephritis;
Membranoproliferative glomerulonephritis;
Dense deposit disease;
Alternative complement pathway
- MeSH:
Complement Activation;
Complement Pathway, Alternative;
Dichlorodiphenyldichloroethane;
Glomerular Basement Membrane;
Glomerulonephritis;
Glomerulonephritis, Membranoproliferative;
Microscopy, Electron;
Microscopy, Fluorescence;
Pathology;
Prevalence
- From:Childhood Kidney Diseases
2019;23(2):93-99
- CountryRepublic of Korea
- Language:English
-
Abstract:
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence microscopy. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are subclasses of C3 glomerulopathy that are distinguishable by electron microscopy. Highly electron-dense transformation of glomerular basement membrane is characteristic of DDD. C3GN should be differentiated from post-infectious glomerulonephritis and other immune complex-mediated glomerulonephritides showing C3 deposits.
