Clinical impacts of inflammatory markers and clinical factors in patients with relapsed or refractory diffuse large B-cell lymphoma
- Author:
Do Young KIM
1
;
Moo Kon SONG
;
Joo Seop CHUNG
;
Ho Jin SHIN
;
Deok Hwan YANG
;
Sung Nam LIM
;
Sung Yong OH
Author Information
- Publication Type:Original Article
- Keywords: Derived neutrophil/lymphocyte ratio; Glasgow prognostic score; DLBCL
- MeSH: B-Lymphocytes; Humans; Lymphoma, B-Cell; Multivariate Analysis; Prognosis
- From:Blood Research 2019;54(4):244-252
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Systemic inflammatory response can be associated with the prognosis of diffuse large B cell lymphoma (DLBCL). We investigated the systemic factors significantly related to clinical outcome in relapsed/refractory DLBCL.METHODS: In 242 patients with DLBCL, several factors, including inflammatory markers were analyzed. We assessed for the correlation between the survivals [progression-free survival (PFS) and overall survival (OS)] and prognostic factors.RESULTS: In these patients, a high derived neutrophil/lymphocyte ratio (dNLR) (PFS, HR=2.452, P=0.002; OS, HR=2.542, P=0.005), high Glasgow Prognostic Score (GPS) (PFS, HR=2.435, P=0.002; OS, HR=2.621, P=0.002), and high NCCN-IPI (PFS, HR=2.836, P=0.003; OS, HR=2.928, P=0.003) were significantly associated with survival in multivariate analysis. Moreover, we proposed a risk stratification model based on dNLR, GPS, and NCCN-IPI, thereby distributing patients into 4 risk groups. There were significant differences in survival among the 4 risk groups (PFS, P<0.001; OS, P<0.001).CONCLUSION: In conclusion, dNLR, GPS, and NCCN-IPI appear to be excellent prognostic parameters for survival in relapsed/refractory DLBCL.
