Advances in the simulation of light–tissue interactions in biomedical engineering
10.1007/s13534-019-00123-x
- Author:
Ilya KRASNIKOV
1
;
Alexey SETEIKIN
;
Bernhard ROTH
Author Information
1. Amur State University, Ignat'evskoe shosse 21, Blagoveshchensk, Russia 675027. seteikin@mail.ru
- Publication Type:Review
- Keywords:
Monte Carlo simulation;
Biotissue;
Light-matter interaction;
Scattering and absorbing media
- MeSH:
Biological Science Disciplines;
Biomedical Engineering;
Optogenetics;
Photons;
Spectrum Analysis, Raman;
Tomography, Optical Coherence
- From:
Biomedical Engineering Letters
2019;9(3):327-337
- CountryRepublic of Korea
- Language:English
-
Abstract:
Monte Carlo (MC) simulation for light propagation in scattering and absorbing media is the gold standard for studying the interaction of light with biological tissue and has been used for years in a wide variety of cases. The interaction of photons with the medium is simulated based on its optical properties and the original approximation of the scattering phase function. Over the past decade, with the new measurement geometries and recording techniques invented also the corresponding sophisticated methods for the description of the underlying light–tissue interaction taking into account realistic parameters and settings were developed. Applications, such as multiple scattering, optogenetics, optical coherence tomography, Raman spectroscopy, polarimetry and Mueller matrix measurement have emerged and are still constantly improved. Here, we review the advances and recent applications of MC simulation for the active field of the life sciences and the medicine pointing out the new insights enabled by the theoretical concepts.
