Estrogen-secreting adrenocortical carcinoma
- Author:
You JEONG
1
;
Sung Chul CHO
;
Hee Joon CHO
;
Ji Soo SONG
;
Joon Seog KONG
;
Jong Wook PARK
;
Yun Hyi KU
Author Information
- Publication Type:Case Report
- Keywords: Adrenal gland neoplasm; Adrenocortical carcinoma, Estrogen; Gynecomastia
- MeSH: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aldosterone; Dehydroepiandrosterone Sulfate; Estradiol; Gynecomastia; Humans; Hydrocortisone; Incidence; Male; Middle Aged; Radiotherapy, Adjuvant; Recurrence
- From:Yeungnam University Journal of Medicine 2019;36(1):54-58
- CountryRepublic of Korea
- Language:English
- Abstract: Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1–2 cases per million. The majority of these tumors secrete cortisol, and a few secrete aldosterone or androgen. Estrogen-secreting adrenocortical carcinomas are extremely rare, irrespective of the secretion status of other adrenocortical hormones. Here, we report the case of a 53-year-old man with a cortisol and estrogen-secreting adrenocortical carcinoma. The patient presented with gynecomastia and abdominal discomfort. Radiological assessment revealed a tumor measuring 21×15.3×12 cm localized to the retroperitoneum. A hormonal evaluation revealed increased levels of estradiol, dehydroepiandrosterone sulfate, and cortisol. The patient underwent a right adrenalectomy, and the pathological examination revealed an adrenocortical carcinoma with a Weiss' score of 6. After surgery, he was treated with adjuvant radiotherapy. Twenty-one months after treatment, the patient remains alive with no evidence of recurrence.
