Repeated Pulmonary Metastasectomy in Patients with Osteosarcoma.
- Author:
Jin Gu LEE
1
;
Dae Joon KIM
;
Kyoo Ho SHIN
;
In Kyu PARK
;
Kyung Young CHUNG
;
Seung Jun SONG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Korea. kdjcool@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Metastasectomy;
Lung neoplasms;
Neoplasm metastasis;
Osteosarcoma
- MeSH:
Female;
Humans;
Lung Neoplasms;
Metastasectomy*;
Neoplasm Metastasis;
Osteosarcoma*;
Retrospective Studies;
Survival Rate;
Survivors
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2007;40(9):607-612
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Surgical resection is a standard treatment for pulmonary metastases in patients with osteosarcoma, but the role of performing repeated resections is not clear. This study was designed to clarify the feasibility of performing a repeated pulmonary metastasectomy and the prognostic factors for pulmonary metastases in patients with osteosarcoma. MATERIAL AND METHOD: Between January 1990 and July 2005, 62 patients with osteosarcoma were diagnosed with pulmonary metastases and 36 patients underwent pulmonary resection. We reviewed the patients retrospectively. RESULT: The total number of pulmonary metastasectomies was 62 in 36 patients. Among 36 patients, 18 had a second metastasectomy, 7 had a third metastasectomy, and one patient had a fourth metastasectomy. There was no distinctive difference between the first and second metastatectomy in terms of median survival time, and the 3-year and 5-year survival rate (first resection: 20.5 months, 32.6% and 29.4%; second resection: 11.3 months, 34.9% and 34.%). However, the median survival time (7.1 months) was shorter in patients with a third metastatectomy than in patients with one metastatectomy (p=0.01). In long-term survivors, the number of female patients, patients with a disease free time longer than 12 months, patients with a single metastasis and patients with anatomic resection was larger when compared to non-long term survivors, but showed no statistical significance. CONCLUSION: Repeated pulmonary metastasectomy is expected to prolong survival time in patients with osteosarcoma, and is expected to increase long-term survival in selected cases. Further studies with a large number of patients are necessary.
