Pulmonary Resection for Invasive Pulmonary Aspergillosis in Hematological Malignancy Patients.
- Author:
Young Jo SA
1
;
Jae Kil PARK
;
Yong Han KIM
;
Sang Yong NAM
;
Sung Bo SIM
;
Sun Hee LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, St. Mary's Hospital, Catholic University College of Medicine, Korea. jaekpark@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Hematologic disease;
Aspergillosis, lung;
Surgical operation
- MeSH:
Bone Marrow;
Fistula;
Hematologic Diseases;
Hematologic Neoplasms*;
Hemorrhage;
Humans;
Immunocompromised Host;
Incidence;
Invasive Pulmonary Aspergillosis*;
Medical Records;
Mortality;
Postoperative Complications;
Prognosis;
Pulmonary Aspergillosis;
Recurrence;
Retrospective Studies;
Wound Infection
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2007;40(9):617-623
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Invasive pulmonary aspergillosis, a frequent fungal infection in immunocompromised patients, is known to have a poor prognosis despite the use of antifungal therapy in leukemic patients. We studied the outcome of surgical resection of invasive pulmonary aspergillosis where bleeding tendency, localized recurrence of infection, and incidence could be reduced. MATERIAL AND METHOD: We retrospectively reviewed 14 patients with a hematological malignancy where invasive pulmonary aspergillosis was diagnosed during the 10 years between 1998 and 2007. From the medical records, we reviewed the type and treatment of the hematological malignancy, including the diagnostic methods of invasive pulmonary aspergillosis, the preoperative hematological conditions and their management, and the surgical methods and records. We also analyzed the development of postoperative complications and patient mortality, the recurrence of postoperative invasive pulmonary aspergillosis, and if the patients had a bone marrow transplant. RESULT: Fourteen patients with invasive pulmonary aspergillosis and a hematological malignancy underwent a pulmonary lobectomy. One patient had a complication of bronchopleural fistula, but there were no other serious complications such as bleeding or wound infection, and none of the patients died postoperatively. CONCLUSION: We have shown that pulmonary lobectomy is a safe and effective therapy for invasive pulmonary aspergillosis in patients with hematological malignancies that allow further treatment of the hematological malignancy.
