Cognitive Profiles of Lamotrigine in Epilepsy Patients : A Comparative Study with Valproate.
- Author:
Kyung Hun KANG
1
;
Jong Mok LEE
;
Ho Won LEE
;
Doo Kyo JUNG
;
Chung Kyu SUH
;
Soon Hak KWON
;
Sung Pa PARK
Author Information
1. Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea. sppark@mail.knu.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
Adverse effects;
Cognition;
Lamotrigine;
Valproate
- MeSH:
Cognition;
Epilepsy*;
Humans;
Incidence;
Learning;
Retrospective Studies;
Trail Making Test;
Valproic Acid*
- From:Journal of Korean Epilepsy Society
2006;10(2):146-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To identify cognitive effects of lamotrigine (LTG) compared with valproate (VPA) in epilepsy patients after 1 year of treatment. METHODS: Cognitive tests and subjective complaints of 22 patients with LTG monotherapy (50-200 mg/day) were retrospectively compared with those of 22 patients with VPA monotherapy (500-1300 mg/day) at 1 year of medication. RESULTS: LTG group did not show any significant difference in the performance of cognitive tests compared with VPA group. The incidence of cognitive complaints between two drugs were also not different. Both groups showed a better performance of list learning and Trail Making Test type A after antiepileptic drug medication. CONCLUSION: The impact of LTG and VPA monotherapy on cognitive functioning is similar. Both drugs may not be harmful or rather slightly beneficial for cognitive functions.
