A Case of Acute Graft versus Host Disease after Liver Transplantation.
10.4285/jkstn.2013.27.1.15
- Author:
Hyun Ji LEE
1
;
Sun Min LEE
;
Byung Chang KIM
;
Chong Woo CHU
;
Kwang Ho YANG
;
Je Ho RYU
;
Ki Myung MOON
;
Kyung Un CHOI
;
Hyung Hoi KIM
Author Information
1. Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea. hhkim@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Acute;
Graft versus host disease;
Liver transplantation;
HLA antigens
- MeSH:
Carcinoma, Hepatocellular;
Diabetes Mellitus;
Graft vs Host Disease;
Hepatitis, Autoimmune;
Histocompatibility Testing;
HLA Antigens;
Humans;
Leukocytes;
Liver;
Liver Transplantation;
Living Donors;
Risk Factors;
Tissue Donors;
Transplantation, Homologous;
Transplants
- From:The Journal of the Korean Society for Transplantation
2013;27(1):15-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The mortality rate of patients with acute graft versus host disease (GVHD) after liver transplantation is very high. Autoimmune hepatitis and diabetes mellitus (DM) is the risk factors of GVHD. Human leukocyte antigen (HLA)-homozygote donor with one way donor-recipient HLA matching is on the risk of fatal GVHD following living donor liver transplantation (LDLT). If recipient has more than one risk factors of GVHD and is going to LDLT, HLA typing is needed to identify donor-dominant one-way HLA matching and helpful to diagnose and treat early and survival of patient will be improved. We report a case of GVHD after liver transplantation for hepatocellular carcinoma and DM who received an allograft from his HLA-homozygous son.
