Gene expression after the application of the fluid-induced shear stress on the gingival fibroblast
- Author:
Mi Hyang JEONG
1
;
Je Yong CHOI
;
Chang Hoon CHAE
;
Seong Gon KIM
;
Dong Seok NAHM
Author Information
1. Department of Orthodontics, College of Dentistry, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Gingival fibroblast;
cDNA microarray;
Fluid induced shear stress
- MeSH:
DNA, Complementary;
Fibroblasts;
Gene Expression;
Homeostasis;
Humans;
Mass Screening;
Mouth;
Mouth Mucosa;
Oligonucleotide Array Sequence Analysis;
RNA;
src Homology Domains
- From:Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
2005;27(5):424-430
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
0.7). The "RUNX-1" was increased its expression in 2 hours group and "RUN and SH3 domain containing 1" was increased its expression in 4 hours group. The "CC020415", "cyclin L1", "interferon regulatory factor1", "early growth response 1", "immediate early response 2", and "immediate early response 3" genes were increased their expression in 2 and 4 hours after FISS application. In conclusion, we could find many genes that were probably related to the FISS application. Interestingly, most of them were placed in similar molecular pathways and these findings improve the reliability of chip data and usefulness in overall screening. From this experiment, we could find many items for further study and it will make improvement in the understanding of intracellular events in response to FISS.]]>
