Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma
- Author:
Hee Sang HWANG
1
;
Yun Yong PARK
;
Su Jin SHIN
;
Heounjeong GO
;
Ja Min PARK
;
Sun Young YOON
;
Jae Lyun LEE
;
Yong Mee CHO
Author Information
- Publication Type:Original Article
- Keywords: Clear Cell Renal Cell Carcinoma; Tyrosine Kinase Inhibitor; Drug Resistance; TNFR1; TNF-α Pathway
- MeSH: Biomarkers; Carcinoma, Renal Cell; Cohort Studies; Dataset; Drug Resistance; Gene Expression; Gene Expression Profiling; Heterografts; Humans; Immunohistochemistry; Protein-Tyrosine Kinases; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha
- From:Journal of Korean Medical Science 2020;35(5):31-
- CountryRepublic of Korea
- Language:English
- Abstract: 10% of labeled tumor cells) of TNF receptor 1 (TNFR1), the protein product of TNFRSF1A gene, was correlated with sarcomatoid dedifferentiation and was an independent predictive factor of clinically unfavorable response and shorter survivals in separated TKI-treated ccRCC cohort.CONCLUSION: TNF-α signaling may play a role in TKI resistance, and TNFR1 expression may serve as a predictive biomarker for clinically unfavorable TKI responses in ccRCC.]]>
