Effects of ziprasidone on serum cholinesterase concentration in schizophrenia patients

VernacularTitle:齐拉西酮对精神分裂症患者血清胆碱酯酶浓度的影响
Author: Huiyu FANG ¹ ; Yanying GU ¹
Author Information

1. .
Keywords: ziprasidone; schizophrenia; serum cholinesterase
From: Journal of Pharmaceutical Practice 2020;38(1):88-90
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of ziprasidone and clozapine on serum cholinesterase (CHE) concentration in schizophrenia patients. Methods 126 schizophrenia patients were randomly divided into the observation group and the control group. The observation group was treated with ziprasidone. The control group received clozapine. The serum CHE concentration was assayed at 7, 14 and 28 days after treatment. Results ① The PANSS scores in both groups were significantly reduced after treatment, while the control group was lower than the observation group (PANSS score for positive symptoms: 15.3±4.7 vs 22.4±4.8, P<0.01; negative symptoms: 14.6±4.5 vs 21.8±5.2, P<0.01; general psychiatric symptoms: 13.3±3.4 vs 19.2±3.9, P<0.01). ② CHE levels were decreased in both groups after treatment. The control group exhibited greater decrease than the observation group. ③ The observation group had lower adverse reaction rate (34.9%) compared to control group (71.4%). Conclusion ziprasidone has weaker inhibitory effect on CHE activity compared to clozapine. This may explain that ziprasidone has lower therapeutic efficacy and better safety profile.