Optimization of the compound herba lysimachiae extraction prosess based on orthogonal experiment and response surface method
10.3969/j.issn.1006-0111.201910001
- VernacularTitle:基于正交试验和响应曲面法优化复方金钱草颗粒提取工艺
- Author:
Pengchao PAN
1
;
Xiaofei CHEN
1
;
Wei CHEN
1
;
Zhiyong GUO
2
;
Yifeng CHAI
3
Author Information
1. .
2. .drguozhiyong@163.com
3. .yfchai@smmu.edu.cn
- Keywords:
compound herba lysimachiae;
extraction prosess;
orthogonal experiment;
response surface method
- From:
Journal of Pharmaceutical Practice
2020;38(1):27-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process of the compound herba lysimachiae by orthogonal experiment and response surface method. Methods The sum of the peak areas of multiple representative components in the compound herba lysimachiae was used as the evaluation index. The ultrasonic extraction time, ultrasonic temperature and ethanol ratio were analyzed to optimize the extraction process conditions by orthogonal experiment and Box-Behnken response surface analysis method. Results Ultrasonic extraction time and ethanol ratio are important factors in the extraction process of the compound herba lysimachiae. The effect of ultrasonic temperature in the extraction process is not significant. The optimal extraction condition for compound herba lysimachiaeare is 10 min ultrasonic extraction time at 55 ℃ with 55% ethanol. Conclusion The optimal extraction process parameters obtained by combining orthogonal experiment and Box-Behnken response surface method can be used for the extraction of representative components from the compound herba lysimachiae and pharmaceutical research in the future.
