Research progress of valproic acid genomics
10.3969/j.issn.1006-0111.201906018
- VernacularTitle:丙戊酸钠基因组学的研究进展
- Author:
Xun ZHOU
1
;
Luojiao TAN
2
;
Hongyu ZHAO
3
;
Shouhong GAO
4
Author Information
1. Department of Pharmacy, Changhai hospital, Naval Medical University, Shanghai 200433, China.
2. Fourth Comprehensive Support Center, Bureau of Retired Veteran Cadres in Beijing, Garrison District, Beijing 100191, China.
3. 65589 Troops of PLA, Daqing 163712, China.
4. Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai 200003,China.gaoshouhong@126.com
- Keywords:
valproic acid;
genomics;
population pharmacokinetic;
individual treatment
- From:
Journal of Pharmaceutical Practice
2020;38(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Valproic acid is a commonly used and broad-spectrum antiepileptic drug in clinical practice with a narrow therapeutic window. Valproic acid has a great individual difference in its metabolism which is influenced by many factors. The gene polymorphism of drug metabolic enzymes is one of the critical factors. Through consulting relevant articles, the affection of genomics and clinical treatment on valproic acid clinical application were reviewed in this paper, which provided a reference for clinical individualized treatment.
