A Rare Case of Primary Thymic Adenocarcinoma Mimicking Small Cell Lung Cancer.
10.4046/trd.2015.78.2.112
- Author:
Eun Na CHO
1
;
Hye Sung PARK
;
Tae Hoon KIM
;
Min Kwang BYUN
;
Hyung Jung KIM
;
Chul Min AHN
;
Yoon Soo CHANG
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. yschang@yuhs.ac
- Publication Type:Case Report
- Keywords:
Adenocarcinoma;
Thymus;
Concurrent Chemoradiotherapies
- MeSH:
Adenocarcinoma*;
Adult;
Aorta, Thoracic;
Biopsy;
Brain;
Chemoradiotherapy;
Cisplatin;
Drug Therapy;
Etoposide;
Follow-Up Studies;
Frontal Lobe;
Hoarseness;
Humans;
Magnetic Resonance Imaging;
Male;
Mediastinum;
Neoplasm Metastasis;
Radiotherapy;
Small Cell Lung Carcinoma*;
Thorax;
Thymus Gland;
Tomography, X-Ray Computed
- From:Tuberculosis and Respiratory Diseases
2015;78(2):112-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary thymic adenocarcinoma is a very rare malignancy of the anterior mediastinum with no standardized treatment. A 36-year-old male patient presented with hoarseness over the past 3 months. A chest computed tomography (CT) scan showed an infiltrative mass to the proximal vessels and aortic arch in left upper mediastinum (4.1x3.1x5.4 cm). Brain magnetic resonance imaging (MRI) showed focal lesions, suggesting metastasis in the left frontal lobe. A thoracoscopic biopsy of the mediastinal mass confirmed a primary thymic adenocarcinoma forming a glandular structure with atypia of tumor cells. The patient received four cycles of systemic chemotherapy, consisting of etoposide and cisplatin, with concurrent radiotherapy (6,000 cGy/30 fractions) to the mediastinal lesion and the metastatic brain lesion (4,200 cGy/12 fractions). A follow-up chest CT scan and brain MRI showed a decrease in the size of the left upper mediastinal mass and brain lesion. We report a rare case of the primary thymic adenocarcinoma with a literature review.
