Agranulocytosis Induced by Ethambutol in a Patient with Pulmonary Tuberculosis.
10.4046/trd.2015.78.2.125
- Author:
Kyoung Min MOON
1
;
Min Soo HAN
;
So Hee CHUNG
;
Ju Ri KIM
;
Jin Young KIM
;
Sun Young JUNG
;
Yongseon CHO
Author Information
1. Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea. hms43@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Agranulocytosis;
Ethambutol;
Tuberculosis, Pulmonary
- MeSH:
Aged;
Agranulocytosis*;
Blood Cell Count;
Diagnosis;
Ethambutol*;
Exanthema;
Fever;
Granulocyte Colony-Stimulating Factor;
Humans;
Isoniazid;
Leukocytes;
Neutropenia;
Neutrophils;
Pyrazinamide;
Rifampin;
Tuberculosis, Pulmonary*
- From:Tuberculosis and Respiratory Diseases
2015;78(2):125-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of agranulocytosis caused by ethambutol in a 79-year-old man with pulmonary tuberculosis. He was referred for fever and skin rash developed on 21th day after antituberculosis drugs (isoniazid, rifampicin, ethambutol, and pyrazinamide) intake. Complete blood count at the time of diagnosis of pulmonary tuberculosis was normal. On the seventh admission day, agranulocytosis was developed with absolute neutrophil count of 70/microL. We discontinued all antituberculosis drugs, and then treated with granulocyte colony-stimulating factor. Three days later, the number of white blood cell returned to normal. We administered isoniazid, pyrazinamide, and ethambutol in order with an interval. However, fever and skin rash developed again when adding ethambutol, so we discontinued ethambutol. After these symptoms disappeared, we added rifampicin and ethambutol in order with an interval. However after administering ethambutol, neutropenia developed, so we discontinued ethambutol again. He was cured with isoniazid, rifampicin, and pyrazinamide for 9 months.
