Potential predictors for chemotherapeutic response and prognosis in epithelial ovarian, fallopian tube and primary peritoneal cancer patients treated with platinum-based chemotherapy
- Author:
Dhammapoj JEERAKORNPASSAWAT
1
;
Prapaporn SUPRASERT
Author Information
- Publication Type:Original Article
- Keywords: Neutrophil; Lymphocyte; Platelet; Ovarian cancer; Platinum
- MeSH: Ascites; Blood Platelets; Drug Therapy; Fallopian Tubes; Female; Humans; Lymphocytes; Medical Records; Multivariate Analysis; Neutrophils; Odds Ratio; Ovarian Neoplasms; Platinum; Prognosis; Retrospective Studies; ROC Curve
- From:Obstetrics & Gynecology Science 2020;63(1):55-63
- CountryRepublic of Korea
- Language:English
- Abstract: 3.38, PLR >210, CA125 >365, advanced stage, suboptimal disease, serous type, and ascites were significant predictive factors for platinum resistance. However, only NLR >3.38 and advanced stage were independent predictive factors with an adjusted odds ratio of 1.880 and 3.333, respectively. Regarding factors associated with poor survival outcomes, only PLR >210 and advanced stage were independent factors, with a hazard ratio of 1.578 and 3.994, respectively.CONCLUSION: High NLR and advanced stage were potential independent predictive factors for platinum resistance, whereas high PLR and advanced stage were potential independent predictive factors for poor survival outcomes.]]>
