Literature Survey on Environmental Exposure to Antineoplastic Agents:
- VernacularTitle:抗がん薬における環境曝露の実態調査に関する文献的考察
- Author:
Hiromu TANIGAWA
1
;
Atsuko SONE
2
;
Tadashi YANO
2
;
Satoshi ICHIKAWA
2
;
Sho ISHIKAWA
2
;
Dan KAMBAYASHI
3
;
Masayoshi HIROHARA
1
;
Kazuki KUSHIDA
1
Author Information
- Keywords: antineoplastic agents; environmental contamination; environmental monitoring; surface contamination
- From:Japanese Journal of Drug Informatics 2019;21(3):95-103
- CountryJapan
- Language:Japanese
- Abstract: Objective: In late 1970s, occupational exposure to antineoplastic agents was reported. Various countries, including Japan, have published guidelines for handling antineoplastic agents. Surveys are still being conducted to determine the levels of environmental exposure to antineoplastic agents at individual hospitals, and incidents of contamination are often reported. This study provides details regarding a literature survey conducted to evaluate the actual state of environmental contamination by antineoplastic agents and identify the related issues in order to promote environmental monitoring.Methods: The literature search was carried out from January 1, 1990 to July 31, 2017. PubMed and Ichushi-Web were searched with the following keywords: “antineoplastic agents,” “occupational exposure,” “surface contamination,” and “environmental monitoring.”Results: Following the literature search, 117 papers were included in the analysis. The findings showed that contamination by antineoplastic agents was widely reported in hospitals and places where antineoplastic drugs were not handled. The findings of this study regarding the actual state of environmental exposure are partial, as there is a lack of information on retail pharmacies and homes of outpatients who have received chemotherapy.Discussion: Therefore, further investigation is warranted. In addition, according to the current Japanese guidelines, published in 2015, environmental surveillance is not required to reduce contamination by antineoplastic agents. To promote environmental monitoring, we feel that it is necessary to determine a new survey method and the clarify optimum interval of environmental monitoring.
