Individualized induction of immune tolerance and regulatory T cell
10.3969/j.issn.1674-7445.2020.01.002
- VernacularTitle:个体化免疫耐受的诱导与调节性T细胞
- Author:
Ling LYU
1
;
Xuhao NI
Author Information
1. Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Immune tolerance;
Operational immune tolerance;
Immune rejection;
Transplantation immunity;
Regulatory T cell;
Translational medicine
- From:
Organ Transplantation
2020;11(1):8-
- CountryChina
- Language:Chinese
-
Abstract:
The induction of immune tolerance is an essential component and the utmost goal in the field of organ transplantation immunity, which depends upon the recognition and presentation of transplantation antigens, the activation and response of the immune system and other immune essence. However, before successfully inducing immune tolerance, how to carry out individualized induction of immune tolerance in organ transplant recipients to optimize the combination of immunosuppressive agents and individualized treatment and achieve the ideal state of optimal prevention and treatment of immune rejection and minimal adverse reactions, remains to be further resolved by the organ transplantation practitioners. Based on the reports of international core journals, the individualized induction strategy of immune tolerance and the future prospects were reviewed in this article from the following aspects including the mechanism underlying induction of immune tolerance, realization of operational immune tolerance, novel strategy of individualized induction of immune tolerance and application of regulatory T cell in individualized immune tolerance in combination with clinical and laboratory research results of regulatory T cell in our center.
