Broadband subharmonic active cavitation imaging with high cavitation to tissue ratio.
10.7507/1001-5515.201812053
- Author:
Xuejin MA
1
,
2
;
Kun GAO
3
;
Na WANG
3
;
Hui ZHONG
4
Author Information
1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R.China
2. Imaging Department, The Third Affiliated Hospital of Zunyi Medical University, The First People's Hospital of Zunyi, Zunyi, Guizhou 563000, P.R.China.
3. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R.China.
4. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R.China.bmezhonghui@mail.xjtu.edu.cn.
- Publication Type:Journal Article
- Keywords:
broadband subharmonic cavitation imaging;
cavitation-to-tissue ratio;
high-intensity focused ultrasound;
pulse inversion technology
- MeSH:
High-Intensity Focused Ultrasound Ablation;
Ultrasonography
- From:
Journal of Biomedical Engineering
2019;36(6):938-944
- CountryChina
- Language:Chinese
-
Abstract:
To improve the cavitation-to-tissue ratio (CTR) of cavitation imaging during the treatment with high-intensity focused ultrasound (HIFU), we proposed a pulse inversion based broadband subharmonic cavitation imaging method (PIBSHI). Due to the fact that the subharmonic signal is a unique nonlinear vibration characteristic of cavitation bubbles, we extracted the broadband subharmonic signal to get a high-CTR cavitation imaging. The simulation showed that the subharmonic signal produced by cavitating bubbles with different sizes varied, and the signal was stronger than other subharmonics when the bubbles' resonant frequency was close to 1/2 subharmonic frequency. Further experiment results demonstrated that compared with the conventional B-mode images, broadband subharmonic cavitation imaging (BSHI) has improved the CTR by 5.7 dB, and the CTR was further improved by 3.4 dB when combined with pulse inversion (PI) technology. Moreover, when the bandwidth was set to 100%~140% of the 1/2 subharmonic frequency in PIBSHI, the CTR was the highest and the imaging showed the optimal quality. The study may have reference value for the development of precise cavitation imaging during HIFU treatment, and contribute to improve the safety of HIFU treatment.
