Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial.
10.1016/j.joim.2019.11.006
- Author:
Gerli E G HERR
1
;
Fábio Goulart DA SILVA
1
;
Francisco José CIDRAL-FILHO
2
;
Fabricia PETRONILHO
3
;
Lucinéia Gainski DANIELSKI
3
;
Mariana Pereira DE SOUZA GOLDIM
3
;
Afonso Shiguemi Inoue SALGADO
4
,
5
;
Franciane BOBINSKI
2
;
Daniel Fernandes MARTINS
6
;
Eliane R WINKELMANN
7
,
8
Author Information
1. Integral Health Care, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ) and University of Cruz Alta (UNICRUZ), Ijuí 98700-000, RS, Brazil.
2. Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça 88137-270, SC, Brazil.
3. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão 88704-900, SC, Brazil.
4. Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça 88137-270, SC, Brazil
5. Integrative Physical Therapy Residency, Philadelphia University Center, Londrina 86020-000, PR, Brazil.
6. Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça 88137-270, SC, Brazil. Electronic address: daniel.martins4@unisul.br.
7. Integral Health Care, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ) and University of Cruz Alta (UNICRUZ), Ijuí 98700-000, RS, Brazil
8. Laboratory of Exercise Physiopathology, Department of Life Sciences (DCVida), Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ), Ijuí 98700-000, RS, Brazil.
- Publication Type:Journal Article
- Keywords:
Bioceramic wrap;
Far-infrared radiation;
Oxidative stress;
Quality of life;
Randomized controlled trial;
Wound healing
- From:
Journal of Integrative Medicine
2020;18(1):26-34
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Venous ulcer represents the most advanced stage of chronic venous insufficiency. It is an important public health problem and has a significant impact on patients' quality of life due to chronic pain, inability to work, need for hospitalization and frequent outpatient follow-up.
OBJECTIVE:We investigated the treatment benefits of far-infrared ceramic (cFIR), in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores, quality of life, serum bio-markers of oxidative stress and antioxidant defense enzymes.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS:This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul, Brazil. We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days.
MAIN OUTCOME MEASURES:The following evaluations were conducted at baseline and after 15, 30, 60 and 90 days: ulcer healing score, quality of life, and serum markers of oxidative stress and antioxidant enzyme activity.
RESULTS:Patients (n = 24) with lower limb venous ulcers were randomized into two treatment groups. cFIR decreased the ulcer size on day 30 (P = 0.042) and 90 (P = 0.034) and the total ulcer healing scale scores on day 30 (P = 0.049) and 90 (P = 0.02) of the treatment, when compared to baseline. Additionally, cFIR improved tissue type (epithelial tissue) on day 60 (P = 0.022) when compared to baseline evaluation.
CONCLUSION:cFIR clinically improved ulcer healing in patients with lower limb venous ulcers.
TRIAL REGISTRATION:RBR-8c7xzn on ReBEC.
