Risk factors for cow's milk protein allergy in infants: a multicenter survey.
- Author:
Ji-Yong ZHANG
1
;
Shao-Ming ZHOU
;
Shao-Hua WANG
;
Feng-Xuan SUI
;
Wu-Hong GAO
;
Qing LIU
;
Hua-Bo CAI
;
Hong-Ying JIANG
;
Wei-Yan LI
;
Li-Ting WANG
;
Li LI
;
Wei ZHAO
;
Jing YING
;
Qian-Zhen WU
;
Bi-Xia WENG
;
Yong-Mei ZENG
Author Information
1. Department of Pediatrics, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong 518017, China. zymdoctor2006@126.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Cattle;
China;
Female;
Humans;
Infant;
Milk Hypersensitivity;
Milk Proteins;
Pregnancy;
Risk Factors;
Surveys and Questionnaires
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the risk factors for cow's milk protein allergy (CMPA) among infants through a multicenter clinical study.
METHODS:A total of 1 829 infants, aged 1-12 months, who attended the outpatient service of the pediatric department in six hospitals in Shenzhen, China from June 2016 to May 2017 were enrolled as subjects. A questionnaire survey was performed to screen out suspected cases of CMPA. Food avoidance and oral food challenge tests were used to make a confirmed diagnosis of CMPA CMPA. A multivariate logistic regression analysis was used to investigate the risk factors for CMPA.
RESULTS:Among the 1 829 infants, 82 (4.48%) were diagnosed with CMPA. The multivariate logistic regression analysis showed that maternal food allergy (OR=4.91, 95%CI: 2.24-10.76, P<0.05), antibiotic exposure during pregnancy (OR=3.18, 95%CI: 1.32-7.65, P<0.05), and the introduction of complementary food at an age of <4 months (OR=3.55, 95%CI: 1.52-8.27, P<0.05) were risk factors for CMPA, while exclusive breastfeeding (OR=0.21, 95%CI: 0.08-0.58, P<0.05) and the introduction of complementary food at an age of >6 months (OR=0.38, 95%CI: 0.17-0.86, P<0.05) were protective factors.
CONCLUSIONS:The introduction of complementary food at an age of <4 months, maternal food allergy, and antibiotic exposure during pregnancy are risk factors for CMPA in infants.
