N-methyl-D-aspartate Receptor:Potential Role in TreatingNeuraxial Opioid Induced Pruritus.
10.3881/j.issn.1000-503X.11096
- Author:
Xiao TAN
1
;
Le SHEN
1
;
Guang Yu HUANG
1
Author Information
1. Department of Anesthesiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,Chin.
- Publication Type:Journal Article
- Keywords:
N-methyl-D-aspartate receptor;
itching;
opioids
- MeSH:
Analgesics, Opioid;
Humans;
Pruritus;
Receptors, N-Methyl-D-Aspartate
- From:
Acta Academiae Medicinae Sinicae
2019;41(6):851-856
- CountryChina
- Language:Chinese
-
Abstract:
Neuraxial opioid administration is one of the most common methods of anesthesia and analgesia,while itching is the most troublesome adverse effect.The current treatments for neuraxial opioid-induced pruritus still have certain limitations.This article reviews the current treatments and basic scientific findings(including neurotransmitters,opioid receptors,and signaling pathways)of pruritus caused by neuraxial opioids.Based on our recent findings on N-methyl-D-aspartate(NMDA)receptors and pruritus caused by neuraxial opioids,we provide new ideas for the treatment of itching caused by neuraxial opioids.Since NMDA receptors may play a key role in neuraxial opioid-induced pruritus,NMDA receptor antagonists can have certain therapeutic advantages.
