Development and application of optogenetic tools.

Author: Qiyao WEI ¹ ; Chenchen XU ¹ ; Meiyan WANG ¹ ; Haifeng YE ¹
Author Information

1. Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China.
Publication Type:Journal Article
Keywords: light-controlled gene switch; light-controlled signal transduction; optogenetics; spatiotemporal control; synthetic biology
MeSH: Cell Differentiation; Light; Optogenetics; Proteins; Signal Transduction
From: Chinese Journal of Biotechnology 2019;35(12):2238-2256
CountryChina
Language:Chinese
Abstract: Dynamic variations of the cell microenvironment can affect cell differentiation, cell signaling pathways, individual growth, and disease. Optogenetics combines gene-encoded protein expression with optical controlling, and offers a novel, reversible, non-invasive and spatiotemporal-specific research tool to dynamically or reversibly regulate cell signaling pathways, subcellular localization and gene expression. This review summarizes the types of optogenetic components and the involved cellular signaling pathways, and explores the application and future prospects of the light-controlled cell signaling pathways.