Function of tumor infiltrating lymphocytes in solid tumors - a review.

Suhang Bai; Xiaoyue Yang; Nan Zhang; Fuhan Zhang; Zongyi Shen; Na Yang; Wensai Zhang; Changyuan YU; Zhao Yang

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Function of tumor infiltrating lymphocytes in solid tumors - a review.

Author: Suhang BAI ¹ ; Xiaoyue YANG ¹ ; Nan ZHANG ¹ ; Fuhan ZHANG ¹ ; Zongyi SHEN ¹ ; Na YANG ¹ ; Wensai ZHANG ¹ ; Changyuan YU ¹ ; Zhao YANG ¹
Author Information

1. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Publication Type:Journal Article
Keywords: immunotherapy; prognosis; solid tumors; tumor infiltrating lymphocytes
MeSH: Humans; Immunotherapy; Lymphocytes; Lymphocytes, Tumor-Infiltrating; Neoplasms; Prognosis
From: Chinese Journal of Biotechnology 2019;35(12):2308-2325
CountryChina
Language:Chinese
Abstract: Tumor is one of the major diseases threatening human health in the 21st century. Surgical resection, radiotherapy, chemotherapy and targeted therapy are the main clinical treatments for solid tumors. However, these methods are unable to eradicate tumor cells completely, and easily lead to the recurrence and progression of tumor. Tumor immunotherapy is a novel treatment that uses human immune system to control and kill tumor by enhancing or restoring anti-tumor immunity. Tumor immunotherapy has shown to produce long-lasting responses in large numbers of patients, and thereby adoptive immunotherapy and immune checkpoint inhibitors could induce remarkable antigen-specific immune responses. Tumor infiltrating lymphocytes (TILs) are highly heterogeneous lymphocytes existing in tumor tissues and play a crucial role in host antigen-specific tumor immune response. Recent studies show that TILs are closely related to the prognosis of patients during the processes of tumorigenesis and treatment. Adoptive immunotherapy mediated by TILs has displayed favorable curative effect in many solid tumors. This paper reviews the recent progress of TILs in solid tumors.