Applications of engineered intestinal bacteria in disease diagnosis and treatment.
- Author:
Jie ZHU
1
;
Jing YANG
2
;
Yunzi LUO
2
Author Information
- Publication Type:Journal Article
- Keywords: clinical application; disease diagnosis and treatment; engineered bacteria; intestinal bacteria; synthetic biology
- MeSH: Bacteria; High-Throughput Nucleotide Sequencing; Humans; Synthetic Biology
- From: Chinese Journal of Biotechnology 2019;35(12):2350-2366
- CountryChina
- Language:Chinese
- Abstract: Intestinal bacteria interact closely with human health and diseases. With the development of high-throughput sequencing technologies, researchers have discovered the potential of intestinal bacteria in the diagnosis and treatment of diseases. Meanwhile, synthetic biology strategies are applied to engineer these bacteria for clinical applications. These engineered intestinal microbial are constructed by designing editing tools and feedback loops to gain functions of diagnose or targeted therapy. Consequently, these engineered bacteria are capable of sensing, calculating and responding to the environment. In this review, we summarize the recent advances in engineered intestinal bacteria in disease diagnosis and treatment. Furthermore, we also discuss the current status and future prospect of the engineered intestinal bacteria regarding their clinical applications, market, and safety issues.
