Comparison of Resistance to gamma-Irradiation between Cryptosporidium parvum and Cryptosporidium muris Using In Vivo Infection.
10.3347/kjp.2011.49.4.423
- Author:
Sejoung YOON
1
;
Jae Ran YU
Author Information
1. Department of Environmental and Tropical Medicine, Konkuk University, School of Medicine, Seoul 143-701, Korea. maria205@kku.ac.kr
- Publication Type:Brief Communication ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Cryptosporidium parvum;
Cryptosporidium muris;
mouse infectivity;
radioresistance
- MeSH:
Animals;
Cryptosporidiosis/*parasitology/radiotherapy;
Cryptosporidium/physiology/*radiation effects;
Cryptosporidium parvum/physiology/*radiation effects;
Feces/parasitology;
Female;
*Gamma Rays;
Humans;
Mice;
Mice, Inbred C57BL;
Oocysts/radiation effects;
Specific Pathogen-Free Organisms
- From:The Korean Journal of Parasitology
2011;49(4):423-426
- CountryRepublic of Korea
- Language:English
-
Abstract:
In the genus Cryptosporidium, there are more than 14 species with different sizes and habitats, as well as different hosts. Among these, C. parvum and C. hominis are known to be human pathogens. As C. parvum can survive exposure to harsh environmental conditions, including various disinfectants or high doses of radiation, it is considered to be an important environmental pathogen that may be a threat to human health. However, the resistance of other Cryptosporidium species to various environmental conditions is unknown. In this study, resistance against gamma-irradiation was compared between C. parvum and C. muris using in vivo infection in mice. The capability of C. muris to infect mice could be eliminated with 1,000 Gy of gamma-irradiation, while C. parvum remained infective in mice after up to 1,000 Gy of gamma-irradiation, although the peak number of oocysts per gram of feces decreased to 16% that of non-irradiated oocysts. The difference in radioresistance between these 2 Cryptosporidium species should be investigated by further studies.
