New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases.
10.1016/j.apsb.2019.11.016
- Author:
Jian LU
1
;
Xuyang SHANG
1
;
Weiguo ZHONG
1
;
Yuan XU
2
;
Rong SHI
3
;
Xin WANG
1
Author Information
1. Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
2. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
3. Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
CYP, cytochrome P450;
CYP1A;
EOAs, cis-epoxyoctadecenoics;
Endogenous substances;
FSH, follicle stimulating hormone;
HODEs, hydroxyoctadecdienoic acids;
IQ, 2-amino-3-methylimidazo [4,5-f] quinoline;
KO, knockout;
LIF/STAT3, inhibiting leukemia inhibitory factor/signal transducer and activator of transcription 3;
Metabolism and disease;
PhIP, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine;
SNPs;
SNPs, single nucleotide polymorphisms;
WT, wild type;
Xenobiotics;
t-RA, all-trans-retinoic acid;
t-ROH, all-trans-retinol
- From:
Acta Pharmaceutica Sinica B
2020;10(1):91-104
- CountryChina
- Language:English
-
Abstract:
Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.
