Significance of Bone Marrow Unclassifiable Cells in Diagnosis of Fever of Unknown Origin.
10.19746/j.cnki.issn.1009-2137.2019.06.022
- Author:
Juan ZHAO
1
;
Wen-Juan WANG
1
;
Ning FU
2
;
Yun-Ru CHEN
3
;
Ya-Lin LIU
4
Author Information
1. Departement of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Provinc, China.
2. Departement of Internal Medicine, The Yuyang District Traditional Chinese Medical Hospital,Yulin 719000, Shaanxi Province, China.
3. Departement of infectious disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
4. Departement of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Provinc, China E-mail: 1084749721@qq.com.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Bone Marrow Cells;
Bone Marrow Examination;
Fever of Unknown Origin;
Humans;
Retrospective Studies
- From:
Journal of Experimental Hematology
2019;27(6):1845-1849
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical significance of bone marrow unclassifiable cells in diagnosis of fever of unknown origin(FUO).
METHODS:The clinical data of 60 patients with FUO admitted in the first affiliated hospital of Xi'an Jiaotong university from June 2014 to May 2016 were collected, and 60 patients with FUO were divided into 2 group: group A(30 cases) in which the unclassifiable cells in bone marrow were observed by bone marrow examination, and group B(30 cases) in which the unclassifiable cells in bone marrow not were found by bone marrow examination. The clinical characteristics, bone marrow features, immunophenotypes of bone marrow cells and prognosis of patients in 2 groups were analyzed retrospectively.
RESULTS:Out of 30 patients in group A, 18 were diagnosed as malignant tumors including 12 cases of lymphoma, while out of 30 patients in group B, 5 cases were diagnosed as malignant tumor, including 3 cases of lymphoma. For the patients with non-tumor diseases, the bone marrow unclassifiable cells disappeared after the patients condition was improved.
CONCLUSION:The bone marrow examination including the smear and biopsy shonld be performed routinely for the patients with FUO. If the unclassifiable cells are observed morphologically in bone marrow of patients with FUO, the disease of patients should be considered as malignant tumor, especially, lymphoma.
