Correlation of Peripheral Blood T Lymphocyte Subsets with Prognosis of Elderly Patients with Newly Diagnosed Multiple Myeloma.
10.7534/j.issn.1009-2137.2019.06.027
- Author:
Jie DING
1
;
Yan GU
1
;
Si-Shu ZHAO
1
;
Yu-Jie WU
1
;
Qing-Lin SHI
1
;
Xiao-Yan QU
1
;
Jian-Yong LI
1
;
Li-Juan CHEN
2
Author Information
1. Department of Hematology . The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital. Nanjing 210029, Jiangsu province, China.
2. Department of Hematology . The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital. Nanjing 210029, Jiangsu province, China,E-mail: chenljb@126.com.
- Publication Type:Journal Article
- MeSH:
Aged;
CD4-CD8 Ratio;
Flow Cytometry;
Humans;
Lymphocyte Count;
Lymphocyte Subsets;
Multiple Myeloma;
Prognosis;
T-Lymphocyte Subsets
- From:
Journal of Experimental Hematology
2019;27(6):1876-1880
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression level of T lymphocyte subsets in elderly patients with newly diagnosed multiple myeloma (NDMM), and to evaluated the prognostic value of T lymphocytic abnormalities in elderly NDMM patients.
METHODS:Pretreated peripheral blood of 39 newly diagnosed elder patients with MM was tested by multi-parameter flow cytometry (MFC) to quantitatively detect T lymphocyte subsets, including CD4T cell, CD8T cell, and CD4/CD8 ratio. The prognostic values T-lymphocyte subset were evaluated in newly diagnosed elderly patients with MM.
RESULTS:The median follow-up time was 21.5 (range, 3.0-66.0) months. Absolute counts of CD4T cell and CD4/CD8 ratio positively correlated with prognosis. In the multivariate COX analysis, lower CD4/CD8 ratio and CD4T cell counts were identified to be independent adverse prognostic factors for OS.
CONCLUSION:Lower CD4/CD8 ratio and CD4T cell counts at initial diagnosis are independent unfavorable prognostic factors for elderly patients with MM, and T lymphocyte subsets are crucial indicators for MM patients' prognosis.
