Effects of Recombinant Human Thrombopoietin on Funtion of T and B Lymphocyte in Prieary ITP Patients.
10.7534/j.issn.1009-2137.2019.06.041
- Author:
Hong-Qiang LUO
1
;
Yong-Gen ZHONG
2
;
Wei-Ying FEN
2
Author Information
1. Department of Hematology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China,E-mail: 13456569897@163.com.
2. Department of Hematology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
B-Lymphocytes;
Humans;
Purpura, Thrombocytopenic, Idiopathic;
Th1 Cells;
Th2 Cells;
Thrombopoietin
- From:
Journal of Experimental Hematology
2019;27(6):1962-1965
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the changes of Th1 and Th2 type cytokines and B lymphocyte level and their clinical significance in idiopathic thrombocytopenic purpura (ITP) patients treated by recombinant human thrombopoietin (rhTPO).
METHODS:The peripheral blood levels of Th1 and Th2 type of cytokines and B lymphocyte were estimated by CBA in 48 patients with ITP, and compared with those in 35 control persons of heath examination.
RESULTS:Before treatment, the levels of Th1 type cytokines and B lymphocyte in 48 patients with ITP were higher, and the levels of Th2 type cytokines were lower than those of healthy controls (P＜0.05). The levels of the peripheral blood CD19 cells, CD5CD19 cells, IL-2 expression negatively correlated with Plt counts in ITP patients (P＜0.05), the levels of IL-4 positively correlated with Plt counts (P＜0.05). After treatment with rhTPO, the levels of Th1 type cytokines and B lymphocytes in 48 patients with ITP significantly decreased, and the levels of Th2 type cytokines significantly increased in comparison with those before treatment (P＜0.05).
CONCLUSION:Peripheral blood Th1 and Th2 type cytokines express abnormally and level of B lymphocytes increases significantly in ITP patinets. The disease severity correlats with the levels of Th1 and Th2 type cytokines and B lymphocytes. Platelets increase after rhTPO treatment, showing that rhTPO can play an important role in regulating Th1 and Th2 immunologic balance and B lymphocyte level in ITP patients.
