Research Progress of m6A-Methylation in Acute Leukemia-Review.
10.7534/j.issn.1009-2137.2019.06.050
- Author:
Qiu-Ni CHEN
1
;
Yue CHEN
1
;
Ting-Ting JI
1
;
Liang YU
2
Author Information
1. Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China,Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
2. Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China,Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China,E-mail: yuliangha@163.com.
- Publication Type:Journal Article
- MeSH:
DNA Methylation;
Epigenesis, Genetic;
Humans;
Leukemia
- From:
Journal of Experimental Hematology
2019;27(6):2014-2018
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic abnormalities play an important role in the pathogenesis of hematological malignancies, especially acute leukemia (AL). Similar to DNA methylation and histone modifications, RNA methylation is another important epigenetic modification. m6A methylation is one of the most prevalent and extensively studied RNA methylation. m6A methylation is involved in many biological and pathological process. Recent studies have found that m6A methylation is involved in the occurrence, development and drug-resistance of AL. This review focuses on the research progress of m6A methylation in AL.
